GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs881375 | 1 | rs10117059 | chr9:123653477 | TRAF1 | chr9:123664672-123691479:- | 0.1 | 4.75 | 2.36E-6 | Rheumatoid arthritis |
| BRCA | cis | rs116988415 | 1 | rs1012376 | chr14:65294790 | CHURC1 | chr14:65381140-65411309:+ | 0.27 | 4.48 | 8.09E-6 | Daytime sleep phenotypes |
| BRCA | cis | rs10496034 | 1 | rs1012603 | chr2:55274531 | CCDC88A | chr2:55514978-55647057:- | -0.16 | -3.46 | 0.000563 | Refractive astigmatism |
| BRCA | cis | rs1466788 | 1 | rs10127539 | chr1:110620117 | ALX3 | chr1:110602998-110613322:- | -0.14 | -4.17 | 3.36E-5 | Blood metabolite levels |
| BRCA | cis | rs910316 | 1 | rs10136948 | chr14:75511075 | EIF2B2 | chr14:75469612-75476292:+ | 0.19 | 5.35 | 1.07E-7 | Height |
| BRCA | cis | rs910316 | 1 | rs10136948 | chr14:75511075 | MLH3 | chr14:75480467-75518235:- | 0.21 | 6.44 | 1.76E-10 | Height |
| BRCA | cis | rs12436436 | 1 | rs10139204 | chr14:24382905 | AP1G2 | chr14:24028777-24037279:- | -0.19 | -3.82 | 0.000139 | Bipolar disorder |
| BRCA | cis | rs12436436 | 1 | rs10139204 | chr14:24382905 | CMA1 | chr14:24974712-24977471:- | -0.16 | -3.41 | 0.000673 | Bipolar disorder |
| BRCA | cis | rs12436436 | 1 | rs10139204 | chr14:24382905 | NGDN | chr14:23938898-23947401:+ | -0.21 | -3.47 | 0.000534 | Bipolar disorder |
| BRCA | cis | rs12436436 | 1 | rs10139204 | chr14:24382905 | RABGGTA | chr14:24734746-24740803:- | -0.19 | -3.64 | 0.000286 | Bipolar disorder |
| BRCA | cis | rs1982963 | 1 | rs10139288 | chr14:52506486 | NID2 | chr14:52471521-52535946:- | 0.08 | 3.56 | 0.000384 | Waist-to-hip ratio adjusted for body mass index |
| BRCA | cis | rs1014246 | 1 | rs1014244 | chr10:118466150 | C10orf82 | chr10:118423208-118429775:- | -0.13 | -3.76 | 0.000181 | Age at smoking initiation in chronic obstructive pulmonary disease |
| BRCA | cis | rs1014246 | 1 | rs1014246 | chr10:118466042 | C10orf82 | chr10:118423208-118429775:- | -0.13 | -3.76 | 0.000181 | Age at smoking initiation in chronic obstructive pulmonary disease |
| BRCA | cis | rs1014897 | 1 | rs1014897 | chr20:895457 | PSMF1 | chr20:1093906-1148424:+ | -0.14 | -3.46 | 0.000567 | Posterior cortical atrophy and Alzheimer's disease |
| BRCA | cis | rs11622475 | 1 | rs10149651 | chr14:104394440 | TDRD9 | chr14:104394817-104519002:+ | -0.41 | -10.56 | 7.07E-25 | Bipolar disorder |